That is why, at MNM, we are working on different ways to tackle this problem. In our recent study, we propose three feature extraction methods, called DBFE, that facilitate classifier learning from distributions of genomic variants. The proposed approaches use binning, clustering, and kernel density estimation to produce features that discriminate between two groups of patients. Experiments on genomes of ovarian, lung, and breast cancer patients show that the proposed approaches are capable of automatically identifying genomic biomarkers associated with cancer subtypes and clinical response to oncological treatment. Moreover, the extracted features are highly interpretable and can be used alongside unsupervised learning methods to analyze genomic samples.