Publication

A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection

J. Casanova, H.C. Su, COVID Human Genetic Effor, L. Abel, A. Aiuti, S. Almuhsen, A.AArias, P. Bastard, C.Biggs, D.Bogunovic, B.Boisson, S.Boisson-Dupuis, A. Bolze, A. Bondarenko, A. Bousfiha, P.Brodin, J. Bustamante, M. Butte, G. Casari, M. Ciancanelli, A. Cobat, A. Condino-Neto, M. Cooper, C. Dalgard, S. Espinosa, H. Feldman, J.Fellay, J.L. Franco, D. Hagin, Y. Itan, E. Jouanguy, C. Lucas, D. Mansouri, I. Meyts, J. Milner, T. Mogensen, T. Morio, L. Ng, L.D. Notarangelo, S. Okada, T. Ozcelik, P. S. Palacín, A. Planas, C. Prando, A. Puel, A. Pujol, C. Redin, L. Renia, J.C. Rodriguez, G. LluisQuintana-Murci, V. Sancho-Shimizu, V. Sankaran, M.R.J.Seppänen, M. Shahrooei, A. Snow, A.Spaan, S. Tangye, J.P. Tur, S. Turvey, D.C. Vinh, H. Bernuth, X. Wang, P. Zawadzki, Q. Zhang and S.Zhang et al.

Published
June 11, 2020
journal
DOI
https://doi.org/10.1016/j.cell.2020.05.016
Covid-19
SARS-COV-2
Human Genetic Effort
Biomarkers
SARS-CoV-2 infection displays immense inter-individual clinical variability, ranging from silent infection to lethal disease.

The role of human genetics in determining clinical response to the virus remains unclear. Studies of outliers—individuals remaining uninfected despite viral exposure and healthy young patients with life-threatening disease—present a unique opportunity to reveal human genetic determinants of infection and disease.

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A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection
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