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Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths

P. Bastard, A. Gervais, T. Le Voyer, J. Rosain, Q. Philippot, J. Manry, E. Michailidis, H. Hoffmann, S. Eto, M. Garcia-Prat, L. Bizien, A. Parra-Martínez, R. Yang, L. Haljasmägi, M. Migaud, K. Särekannu, J. Maslovskaja, N. deProst, Y. Tandjaoui-Lambiotte, C. Luyt, B. Amador-Borrero, A. Gaudet, J. Poissy, P. Morel, P. Richard, F. Cognasse, J. Troya, S. Trouillet-Assant, A. Belot, K. Saker, P. Garçon, J. G. Rivière, J. Lagier, S. Gentile, L. B. Rosen, E. Shaw, T. Morio, J. Tanaka, D. Dalmau, P. Tharaux, D. Sene, A. Stepanian, B. Megarbane, V. Triantafyllia, A. Fekkar, J. R. Heath, J. Luis Franco, J. Anaya, J. Solé-Violán, L. Imberti, A. Biondi, P. Bonfanti, R. Castagnoli, O. M. Delmonte, Y. Zhang , A. L. Snow, S. M. Holland, C. M. Biggs, M. Moncada-Vélez, A. Augusto Arias, L. Lorenzo, S. Boucherit, B. Coulibaly, D. Anglicheau, A. M. Planas, F. Haerynck, S. Duvlis, R. L. Nussbaum, T. Ozcelik, S. Keles, A. A. Bousfiha, J. El Bakkouri, C. Ramirez-Santana, S. Paul, Q. Pan-Hammarström, L. Hammarström, A. Dupont, A. Kurolap, C. N. Metz, A. Aiuti, G. Casari, V. Lampasona, F. Ciceri, L. A. Barreiros, E. Dominguez-Garrido, M. Vidigal, M. Zatz, D. van de Beek, S. Sahanic, I. Tancevski, Y. Stepanovskyy, O. Boyarchuk, Y. Nukui, M. Tsumura, L. Vidaur, S. G. Tangye , S. Burrel, D. Duffy, L. Quintana-Murci, A. Klocperk, N. Y. Kann , A. Shcherbina, Y. Lau, D. Leung, M. Coulongeat, J. Marlet, R. Koning, L. Felipe Reyes , A. Chauvineau-Grenier, F. Venet, G. Monneret, M. C. Nussenzweig , R. Arrestier, I. Boudhabhay, H. Baris-Feldman, D. Hagin, J. Wauters, I. Meyts, A. H. Dyer , S. P. Kennelly , N. M. Bourke , R. Halwani, N. Saheb Sharif-Askari , K. Dorgham, J. Sallette, S. Mehlal Sedkaoui , S. AlKhater, R. Rigo-Bonnin, F. Morandeira, L. Roussel, D. C. Vinh , S. Rye Ostrowski , A. Condino-Neto, C. Prando, A. Bondarenko, A. N. Spaan , L. Gilardin, J. Fellay, S. Lyonnet, K. Bilguvar, R. P. Lifton , S. Mane, HGID Lab COVID Clinicians COVID-STORM Clinicians NIAID Immune Response to COVID Group NH-COVAIR Study Group Danish CHGE Danish Blood Donor Study St. James’s Hospital SARS CoV2 Interest group French COVID Cohort Study Imagine COVID-Group The Milieu Intérieur Consortium CoV-Contact Cohort Amsterdam UMC Covid-19 Biobank Investigators COVID. Human Genetic Effort CONSTANCES cohort C-Dijon. Study Cerba HealthCare Etablissement du Sang studygroup M. S. Anderson , B. Boisson, V. Béziat, S. Zhang, E. Andreakos, O. Hermine, A. Pujol, P. Peterson, T. H. Mogensen , L. Rowen, J. Mond, S. Debette, X. de Lamballerie , X. Duval, F. Mentré, M. Zins, P. Soler-Palacin, R. Colobran, G. Gorochov, X. Solanich, S. Susen, J. Martinez-Picado, D. Raoult, M. Vasse, P. K. Gregersen , L. Piemonti, C. Rodríguez-Gallego, L. D. Notarangelo , H. C. Su , K. Kisand, S. Okada, A. Puel, E. Jouanguy, C. M. Rice , P. Tiberghien, Q. Zhang, A. Cobat, L. Abel, J. Casanova et al.

Published
August 20, 2021
journal
DOI
http://doi/10.1126/sciimmunol.abl4340
Covid-19
SARS-COV-2
Risk Factors
Human Genetic Effort
Since the start of the coronavirus disease 2019 (COVID-19) pan-demic in December 2019, more than 200 million people have been infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), resulting in at least 4 million deaths and probably closer  to  7  to  9  million  deaths  worldwide.  

Interindividual  clinical  variability  in  the  course  of  acute  infection  is  vast,  extending  from  silent or mild infection in about 90% of individuals to pneumonia and respiratory failure, both requiring hospitalization, in less than 10 and 2% of cases, respectively. Age is the major epidemiological risk factor for hospitalization or death from pneumonia, the risk doubling with every 5 years of age (1, 2). The frequencies of critical disease and death from COVID-19 are higher in men than in women (3–5).

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