Publication

Rapid response to emerging biomedical challenges and threats

M. Grabowski, J.M. Macnar, M. Cymborowski,. D.R. Cooper, I.G. Shabalin, M. Gilski, D. Brzezinski, M. Kowiel, Z. Dauter, B. Rupp, A. Wlodawer, M. Jaskolskid and W. Minora

Published
March 26, 2021
journal
DOI
https://doi.org//10.1107/S2052252521003018/be5288sup2.xlsx
Covid-19
SARS-COV-2
structural biology
crystallography

In response to the SARS-CoV-2 pandemic, an unprecedented mobilization of the scientific community took place, focused on understanding various properties of the SARS-CoV-2 virus and developing drugs to treat and prevent COVID-19.

In line with the current, structure-based paradigm of drug discovery, structural biology has been among the leading disciplines supporting these efforts. Indeed, since the first structure of a SARS-CoV-2 protein was released at the beginning of February 2020, there has been a flood of three-dimensional models of SARS-CoV-2-related macromolecular targets, mostly determined by X-ray crystallography and cryo-electron microscopy (cryo-EM).

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